With continuous technological advancements in cardiovascular disease treatment, Inclisiran (CAS: 1639324-58-5) has emerged as a landmark small interfering RNA (siRNA) lipid-lowering agent. Its long-acting and precise therapeutic profile drives escalating market demand globally. To support pharmaceutical companies and research institutions in accelerating Inclisiran’s research, development, and manufacturing, we leverage a mature R&D and production platform coupled with stringent quality control standards. We now offer a comprehensive range of high-purity, stable intermediates along the entire synthetic pathway of Inclisiran, providing critical raw material support for your projects.
|
API |
KSM |
CAS No |
|
Inclisiran |
2'-OMe N-Bz Adenosine Amidite |
110782-31-5 |
|
2'-OMe N-iBu Guanosine Amidite |
150780-67-9 |
|
|
2'-OMe N-Ac Cytidine Amidite |
199593-09-4 |
|
|
2'-OMe Uridine Amidite |
110764-79-9 |
|
|
2'-Fluoro N-Bz Adenosine Amidite |
136834-22-5 |
|
|
2'-Fluoro N-iBu Guanosine Amidite |
144089-97-4 |
|
|
2'-Fluoro N-Ac Cytidine Amidite |
159414-99-0 |
|
|
2'-Fluoro Uridine Amidite |
146954-75-8 |
|
|
deoxy Thymidine Amidite |
98796-51-1 |
Core Product Portfolio Covering Key Steps in Inclisiran Synthesis
Drawing on years of specialization in nucleic acid drug intermediates, our product lineup is finely tuned to meet the specific synthetic requirements of Inclisiran. The supplied intermediates cover every crucial segment and modified monomer involved in its complete synthetic process, including but not limited to:
- Modified Nucleoside Intermediates: These cover a variety of ribonucleoside and deoxyribonucleoside derivatives modified at different positions, serving as the essential foundational raw materials for constructing Inclisiran’s oligonucleotide chains.
- Linkers and Activation Intermediates: Special intermediates designed for efficient and specific nucleotide chain elongation and end modification, ensuring highly selective coupling reactions.
- Protective Group Reagents and Derivatives: A comprehensive collection of high-performance protecting groups and modified products to precisely control protection and deprotection steps during synthesis, crucial for maintaining the integrity of functional groups in complex oligonucleotides.
- Customized Intermediates: Tailored synthesis services are available to accommodate client-specific synthetic routes and structural requirements, addressing unique raw material challenges in specialized process steps.
Each intermediate is optimized according to the distinctive features of Inclisiran’s synthetic procedures to guarantee optimal compatibility with subsequent reactions, thereby enhancing overall yield and product purity.
By integrating advanced chemistry expertise with rigorous quality management, we are committed to delivering reliable, high-quality intermediates that accelerate the global development and manufacture of this pivotal siRNA therapeutic. Our solutions aim to empower your Inclisiran projects, ensuring seamless scale-up and robust production in this rapidly evolving field of cardiovascular treatment.
